Potassium Hydroxide → HCID 67196000, compound

Participants

Reaction Steps

To a solution of 3-(4-fluorophenyl)-imidazo[1,5-a]pyrazine-8-carboxylic acid ethyl ester (440.0 mg, 1.54 mmol) in methanol (10 mL) is added in several portions a solution of 85% KOH (330 mg, 4.9 mmol) in water (3 mL) (additional water is added to suspend the solid that precipitated) and the mixture is warmed at reflux. The methanol is removed in vacuo and the residue is diluted with water (15 mL) and made acidic (pH=4) with 1 N aqueous HCl. The solid is collected by filtration washing with water and then ether to afford 3-(4-fluorophenyl)-imidazo[1,5-a]pyrazine-8-carboxylic acid.

Provenance & Evidence