Potassium Hydroxide → HCID 67196007, compound

Participants

Reaction Steps

To a solution of 1-(4-fluorophenyl)-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid ethyl ester (650 mg, 2.3 mmol) in methanol (25 mL) is added in several portions a solution of 85% KOH (1.2 g, 18.2 mmol) in water (15 mL). The mixture is warmed at reflux for 30 minutes and is then diluted with water (20 mL) and washed with ether (2×15 mL). The aqueous layer is made acidic (pH=4) with concentrated HCl and the resulting precipitate is collected by filtration washing with water to afford the title compound.

Provenance & Evidence