反应详情

A mixture of imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester (3.24 g, 18.3 mmol) and N-iodosuccinimide (NIS) (4.11 g, 18.3 mmol) in acetonitrile (50 mL) is stirred at room temperature. After 2 hours, the reaction mixture is quenched with saturated aqueous Na2S2O3 and extracted with EtOAc (3×100 mL). The combined organic layers are washed with water, brine, dried over Na2SO4 and concentrated. The crude material is purified by silica gel chromatography eluting with 80% EtOAc in hexanes to afford 3-iodo-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester. Mp: 99-110° C.

1. customthe reaction mixture is quenched with saturated aqueous Na2S2O3
2. extractionextracted with EtOAc (3×100 mL)
3. washThe combined organic layers are washed with water, brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customThe crude material is purified by silica gel chromatography
7. washeluting with 80% EtOAc in hexanes