反应详情

To a solution of 1-(2-bromo-thiazol-5-yl)-propan-1-ol (180 mg, 0.79 mmol) in dichloromethane (10 mL) is added Dess-Martin periodinane (DMP) (330 mg, 0.79 mmol). After 2 hours, the mixture is diluted with dichloromethane (50 mL), washed with saturated aqueous sodium bicarbonate (50 mL), brine (50 mL), dried over sodium sulfate, filtered and concentrated. The mixture is purified by silica gel chromatography eluting with a gradient of 0-100% EtOAc in hexanes to afford 1-(2-bromo-thiazol-5-yl)-propan-1-one.

1. washwashed with saturated aqueous sodium bicarbonate (50 mL), brine (50 mL)
2. dry with materialdried over sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customThe mixture is purified by silica gel chromatography
6. washeluting with a gradient of 0-100% EtOAc in hexanes