Potassium Carbonate → HCID 52933352, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 6-cyano-1-(4-fluorophenyl)-1H-indole-4-carboxylic acid (6-bromo-pyridin-3-ylmethyl)-amide (75 mg, 0.17 mmol), methanesulfonamide (81 mg, 0.85 mmol), copper (II) trifluoromethanesulfonate (105 mg, 0.290 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (55.2 μL, 0.35 mmol) and potassium carbonate (247 mg, 1.79 mmol) in a sealed tube is added NMP (2.5 mL). The solution is degassed with argon for 3 minutes. The reaction is warmed at 125° C. in a microwave reactor. After 40 minutes, the reaction is diluted with saturated aqueous potassium carbonate (15 mL) and extracted with EtOAc (2×15 mL). The combined organic layers are washed with brine (2×15 mL), dried over magnesium sulfate and concentrated in vacuo. The residue is purified by preparative reversed phase HPLC to afford the title compound.

Provenance & Evidence