HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-methoxyphenol → (3S)-3-(5-Bromo-2-methoxyphenoxy)-1-methylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-methoxyphenol | HCID 142228 | — |
| Reactant | 1-Methyl-3-pyrrolidinol, (+)- | HCID 643504 | — |
| Product | (3S)-3-(5-Bromo-2-methoxyphenoxy)-1-methylpyrrolidine | HCID 66824451 | 30.5% |
Reaction Steps
The title compound was prepared by the method outlined for Preparative Example 63 using 5-bromo-2-methoxy-phenol (1.00 g, 4.93 mmol) and (S)-1-methyl-pyrrolidin-3-ol (593 mg, 5.86 mmol) to afford titled compound as a colorless solid (430 mg, 30%). LC/MS (Method B) 1.17 min, [M+1]+ 286/288.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927546B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-66bc8419a9a3432087c49c0b705dc6d2 |
| Source note | uspto-grants-2015_01 |