Hydrochloric Acid → (S)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(pyrrolidin-1-ylmethyl)piperazine, dihydrochloride

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Reaction Steps

The intermediate (S)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-pyrrolidin-1-ylmethyl-piperazine-1-carboxylic acid tert-butyl ester (300 mg, 0.65 mmol) was then dissolved in 1,4-dioxane (2 mL) and treated with a 4 N solution of hydrogen chloride in 1,4-dioxane (4 mL) and stirred for 3 h. The reaction was then evaporated to afford the title compound as a colorless solid. (280 mg, 99%). LC/MS (Method B) 1.05 min, [M+1]+ 360.

Provenance & Evidence