1,1-Dimethylethyl (2S)-2-(phenylmethyl)-1-piperazinecarboxylate → (S)-5-(3-benzylpiperazin-1-yl)-3-cyclobutyl-1-methyl-1H-indazole

Participants

Reaction Steps

The title compound was prepared by the method outlined for Example 1 using 5-Bromo-3-cyclobutyl-1-methyl-1H-indazole as the aryl halide and (S)-2-benzyl-piperazine-1-carboxylic acid tert-butyl ester as the amine component to afford the title compound as a brown oil (409 mg, 99%). 1H NMR (MeOH-d4) 8.72 (d, J=8.7 Hz, 1H), 7.79 (d, J=8.8 Hz, 1H), 7.32-7.18 (m, 6H), 4.08 (s, 3H), 3.79-3.46 (m, 3H), 3.35-3.34 (m, 1H), 3.31-3.30 (m, 2H), 3.15-3.07 (m, 4H), 2.88-2.77 (m, 5H), 2.69-2.61 (m, 1H). LC/MS (Method B) 2.49 min, [M+1]+ 361.

Provenance & Evidence