Aluminium lithium hydride → HCID 58188995, compound

Participants

Reaction Steps

A solution of intermediate (S)-ethyl 3-(2-benzyl-4-(3-(cyclopentyloxy)-4-methoxyphenyl)piperazin-1-yl)-3-oxopropanoate (117 mg, 0.25 mmol) in THF (2 mL) was treated with a 1 N THF solution of lithium aluminum hydride (500 μL, 0.5 mmol) and stirred for 1 h. After this time the reaction mixture was quenched with ice water (250 μL) followed by a 5% NaOH solution (500 uL) and solid MgSO4. The material was dissolved in EtOAc, filtered and evaporated to afford the title compound as a burgundy colored oil (103 mg, 97%). LC/MS (Method A) 5.15 min, [M+1]+ 425.

Provenance & Evidence