Aluminium lithium hydride → HCID 58189218, compound

Participants

Reaction Steps

A solution of intermediate (S)-ethyl 4-(2-benzyl-4-(3-(cyclopentyloxy)-4-methoxyphenyl)piperazin-1-yl)-4-oxobutanoate (124 mg, 0.25 mmol) in THF (2 mL) was treated with a 1 N THF solution of lithium aluminum hydride (1.0 mL, 1.0 mmol) and stirred for 1 h. After this time the reaction mixture was quenched with ice water (500 μL) followed by a 5% NaOH solution (500 μL) and solid MgSO4. The material was dissolved in EtOAc, filtered and evaporated to afford the title compound as a burgundy colored oil (77 mg. 70%). LC/MS (Method A) 5.22 min, [M+1]+ 439.

Provenance & Evidence