HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-chloro-3-oxopropionate → (S)-3-(2-benzyl-4-(3-isopropoxy-4-methoxyphenyl)piperazin-1-yl)-3-oxopropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-chloro-3-oxopropionate | HCID 118931 | — |
| Reactant | HCID 58189029 | HCID 58189029 | — |
| Product | (S)-3-(2-benzyl-4-(3-isopropoxy-4-methoxyphenyl)piperazin-1-yl)-3-oxopropanoic acid | HCID 66824774 | — |
Reaction Steps
Prepared by the method outlined for Example 127 using chlorocarbonyl-acetic acid ethyl ester and 3(S)-benzyl-1-(3-isopropoxy-4-methoxy-phenyl)-piperazine (Example 9, Compound 97) as starting materials. Product as an oil. LC/MS (Method B) 2.36 min, [M+1]+439.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927546B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-7d4d160a343a4bb6b4afd14005c437e4 |
| Source note | uspto-grants-2015_01 |