Imidazole-4-acetic acid → HCID 178491979, compound

HRID 1423158Notes

Reaction equation

HRID 1423158 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]([OH:9])=O)[N:3]=[CH:2]1.[CH2:10]([C@@H:17]1[NH:22][CH2:21][CH2:20][N:19]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH:32]3[CH2:35][CH2:34][CH2:33]3)[CH:24]=2)[CH2:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([C@H:17]1[CH2:18][N:19]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH:32]3[CH2:35][CH2:34][CH2:33]3)[CH:24]=2)[CH2:20][CH2:21][N:22]1[C:7](=[O:9])[CH2:6][C:4]1[N:3]=[CH:2][NH:1][CH:5]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 96215Imidazole-4-acetic acidHCID 58188985HCID 58188985, compound

Product 1

HCID 178491979HCID 178491979, compound

Procedure

Prepared by the method outlined for Example 189 using (1H-imidazol-4-yl)-acetic acid and 3(S)-benzyl-1-(3-cyclobutoxy-4-methoxy-phenyl)-piperazine as starting material. Product as an oil (20 mg, 62%). LC/MS (Method B) 2.89 min, [M+1]+ 461. Potency class A.

Workup

  1. customPrepared by the method
  2. customLC/MS (Method B) 2.89 min, [M+1]+ 461

Sources & evidence

ORD record
ord-c8ec5935716c42c9ae12cefcae93c6a4
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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