HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1H-tetrazol-5-yl)acetic acid → (S)-1-(2-benzyl-4-(3-isopropoxy-4-methoxyphenyl)piperazin-1-yl)-2-(2H-tetrazol-5-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1H-tetrazol-5-yl)acetic acid | HCID 89031 | — |
| Reactant | HCID 58189029 | HCID 58189029 | — |
| Product | (S)-1-(2-benzyl-4-(3-isopropoxy-4-methoxyphenyl)piperazin-1-yl)-2-(2H-tetrazol-5-yl)ethanone | HCID 58189185 | — |
Reaction Steps
Prepared by the method outlined for Example 189 using (2H-tetrazol-5-yl)-acetic acid and 3(S)-benzyl-1-(3-(1-methylethoxy)-4-methoxy-phenyl)-piperazine (Example 9, Compound 97) as starting materials. Product as an oil. LC/MS (Method B) 2.50 min, [M+1]+ 450. Potency class B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927546B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-5e3af8ade8e145fa92a6592033addb38 |
| Source note | uspto-grants-2015_01 |