2-Pyrimidineacetic Acid → HCID 58189046, compound

HRID 1423169Notes

Reaction equation

HRID 1423169 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][C:8]([OH:10])=O.[CH2:11]([C@@H:18]1[NH:23][CH2:22][CH2:21][N:20]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([O:32][CH:33]3[CH2:36][CH2:35][CH2:34]3)[CH:25]=2)[CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([C@H:18]1[CH2:19][N:20]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([O:32][CH:33]3[CH2:36][CH2:35][CH2:34]3)[CH:25]=2)[CH2:21][CH2:22][N:23]1[C:8](=[O:10])[CH2:7][C:2]1[N:1]=[CH:6][CH:5]=[CH:4][N:3]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 123670982-Pyrimidineacetic AcidHCID 58188985HCID 58188985, compound2×

Product 1

HCID 58189046HCID 58189046, compound

Procedure

Prepared by the method outlined for Example 189 using pyrimidin-2-yl-acetic acid and 3(S)-benzyl-1-(3-cyclobutoxy-4-methoxy-phenyl)-piperazine (Example 7, Compound 95) as starting materials. Product as an oil. LC/MS (Method B) 2.51 min, [M+1]+ 473. Potency class A.

Workup

  1. customPrepared by the method
  2. customLC/MS (Method B) 2.51 min, [M+1]+ 473

Sources & evidence

ORD record
ord-b93c5c89c1424ac994da39b753455b8a
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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