HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-methyl-1H-1,2,4-triazol-5-yl)acetic acid → (S)-1-(2-benzyl-4-(3-(difluoromethoxy)-4-methoxyphenyl)piperazin-1-yl)-2-(5-methyl-1H-1,2,4-triazol-3-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-methyl-1H-1,2,4-triazol-5-yl)acetic acid | HCID 7019477 | — |
| Reactant | (S)-3-benzyl-1-(3-(difluoromethoxy)-4-methoxyphenyl)piperazine | HCID 52920372 | — |
| Product | (S)-1-(2-benzyl-4-(3-(difluoromethoxy)-4-methoxyphenyl)piperazin-1-yl)-2-(5-methyl-1H-1,2,4-triazol-3-yl)ethanone | HCID 58189237 | — |
Reaction Steps
Prepared by the method outlined for Example 189 using (5-methyl-1H-[1,2,4]triazol-3-yl)-acetic acid and (S)-3-benzyl-1-(3-difluoromethoxy-4-methoxy-phenyl)-piperazine (Example 69, Compound 157) as starting materials. Product as an oil. LC/MS (Method B) 2.57 min, [M+1]+ 472. Potency class A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927546B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-57653d74c7864835bb8c5be3095ea77d |
| Source note | uspto-grants-2015_01 |