2-Pyrimidineacetic Acid → HCID 58189126, compound

HRID 1423179Notes

Reaction equation

HRID 1423179 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][C:8]([OH:10])=O.[CH2:11]([C@@H:18]1[NH:23][CH2:22][CH2:21][N:20]([C:24]2[CH:32]=[C:31]3[C:27]([C:28]([CH2:38][CH3:39])=[N:29][N:30]3[CH:33]3[CH2:37][CH2:36][CH2:35]C3)=[CH:26][CH:25]=2)[CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([C@H:18]1[CH2:19][N:20]([C:24]2[CH:32]=[C:31]3[C:27]([C:28]([CH2:38][CH3:39])=[N:29][N:30]3[CH:33]3[CH2:35][CH2:36][CH2:37]3)=[CH:26][CH:25]=2)[CH2:21][CH2:22][N:23]1[C:8](=[O:10])[CH2:7][C:2]1[N:1]=[CH:6][CH:5]=[CH:4][N:3]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 123670982-Pyrimidineacetic AcidHCID 23627567HCID 23627567, compound2×

Product 1

HCID 58189126HCID 58189126, compound

Procedure

Prepared by the method outlined for Example 189 using pyrimidin-2-yl-acetic acid and 6-((S)-3-benzyl-piperazin-1-yl)-1-cyclobutyl-3-ethyl-1H-indazole (Example 56, Compound 144) as starting materials. Product as an oil. LC/MS (Method B) 2.46 min, [M+1]+ 495. Potency class C.

Workup

  1. customPrepared by the method
  2. customLC/MS (Method B) 2.46 min, [M+1]+ 495

Sources & evidence

ORD record
ord-8a35585d4cf34966b31cd71cea3d2686
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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