Imidazole-4-acetic acid → HCID 178491984, compound

HRID 1423190Notes

Reaction equation

HRID 1423190 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]([OH:9])=O)[N:3]=[CH:2]1.[CH:10]([O:13][C:14]1[CH:15]=[C:16]([N:22]2[CH2:27][CH2:26][NH:25][C@@H:24]([CH2:28][CH:29]([CH3:31])[CH3:30])[CH2:23]2)[CH:17]=[CH:18][C:19]=1[O:20][CH3:21])([CH3:12])[CH3:11]>>[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]([N:25]2[CH2:26][CH2:27][N:22]([C:16]3[CH:17]=[CH:18][C:19]([O:20][CH3:21])=[C:14]([O:13][CH:10]([CH3:11])[CH3:12])[CH:15]=3)[CH2:23][C@@H:24]2[CH2:28][CH:29]([CH3:31])[CH3:30])=[O:9])[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 96215Imidazole-4-acetic acidHCID 58189109HCID 58189109, compound2×

Product 1

HCID 178491984HCID 178491984, compound

Procedure

Prepared by the method outlined for Example 189 using 2-(1H-imidazol-4-yl)acetic acid and (S)-1-(3-isopropoxy-4-methoxy-phenyl)-3-isobutyl-piperazine (Example 35, Compound 123) as starting materials. Product as an off-white solid (32%). LC/MS (Method B) 2.52 min, [M+1]+ 415.1. Potency class B.

Workup

  1. customPrepared by the method
  2. customLC/MS (Method B) 2.52 min, [M+1]+ 415.1

Sources & evidence

ORD record
ord-a47f68d737164946b758395c0a4ecb71
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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