2-Pyrimidineacetic Acid → (S)-1-(2-benzyl-4-(3-ethyl-1-isopropyl-1H-indazol-6-yl)piperazin-1-yl)-2-(pyrimidin-2-yl)ethanone

HRID 1423197Notes

Reaction equation

HRID 1423197 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][C:8]([OH:10])=O.[CH2:11]([C@@H:18]1[NH:23][CH2:22][CH2:21][N:20]([C:24]2[CH:32]=[C:31]3[C:27]([C:28]([CH2:36][CH3:37])=[N:29][N:30]3[CH:33]([CH3:35])[CH3:34])=[CH:26][CH:25]=2)[CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([C@H:18]1[CH2:19][N:20]([C:24]2[CH:32]=[C:31]3[C:27]([C:28]([CH2:36][CH3:37])=[N:29][N:30]3[CH:33]([CH3:34])[CH3:35])=[CH:26][CH:25]=2)[CH2:21][CH2:22][N:23]1[C:8](=[O:10])[CH2:7][C:2]1[N:1]=[CH:6][CH:5]=[CH:4][N:3]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 123670982-Pyrimidineacetic AcidHCID 581892466-((S)-3-benzyl-piperazin-1-yl)-1-isopropyl-3-ethyl-1H-indazole

Product 1

HCID 58189167(S)-1-(2-benzyl-4-(3-ethyl-1-isopropyl-1H-indazol-6-yl)piperazin-1-yl)-2-(pyrimidin-2-yl)ethanoneYield 64%

Procedure

Prepared by the method outlined for Example 189 using 2-(pyrimidin-2-yl)acetic acid and 6-((S)-3-benzyl-piperazin-1-yl)-1-isopropyl-3-ethyl-1H-indazole as starting materials. Product was obtained as a colorless solid (64%). LC/MS (Method B) 3.7 min, [M+1]+ 483.

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-9e751f9b953c40bea321c6e4a23f431e
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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