HCID 58189077, compound → HCID 178437960, compound

HRID 1423200Notes

Reaction equation

HRID 1423200 reaction equation
[CH2:1]([C:3]1[NH:7][N:6]=[C:5]([CH2:8][C:9]([O:11]C)=O)[N:4]=1)[CH3:2].[CH2:13]([C@@H:20]1[NH:25][CH2:24][CH2:23][N:22]([C:26]2[CH:34]=[C:33]3[C:29]([C:30]([CH2:39][CH3:40])=[N:31][N:32]3[CH:35]3[CH2:38][CH2:37][CH2:36]3)=[CH:28][CH:27]=2)[CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([C@H:20]1[CH2:21][N:22]([C:26]2[CH:34]=[C:33]3[C:29]([C:30]([CH2:39][CH3:40])=[N:31][N:32]3[CH:35]3[CH2:36][CH2:37][CH2:38]3)=[CH:28][CH:27]=2)[CH2:23][CH2:24][N:25]1[C:9](=[O:11])[CH2:8][C:5]1[NH:4][C:3]([CH2:1][CH3:2])=[N:7][N:6]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 58189077HCID 58189077, compoundHCID 178437641HCID 178437641, compound

Product 1

HCID 178437960HCID 178437960, compoundYield 16%

Procedure

Prepared by the method outlined for Example 275 using methyl (5-ethyl-1H-1,2,4-triazol-3-yl)acetate and 6-((S)-3-benzyl-piperazin-1-yl)-1-cyclobutyl-3-ethyl-1H-indazole as starting materials. Product was obtained as a light yellow solid (16%). LC/MS (Method B) 3.56 min, [M+1]+ 512.

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-df1dcd96dbe5488793e5acdf3a8b102b
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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