HCID 58189077, compound → HCID 178437914, compound

HRID 1423201Notes

Reaction equation

HRID 1423201 reaction equation
[CH:1]([C:4]1[NH:8][N:7]=[C:6]([CH2:9][C:10]([O:12]C)=O)[N:5]=1)([CH3:3])[CH3:2].[CH2:14]([C@@H:21]1[NH:26][CH2:25][CH2:24][N:23]([C:27]2[CH:35]=[C:34]3[C:30]([C:31]([CH2:40][CH3:41])=[N:32][N:33]3[CH:36]3[CH2:39][CH2:38][CH2:37]3)=[CH:29][CH:28]=2)[CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([C@H:21]1[CH2:22][N:23]([C:27]2[CH:35]=[C:34]3[C:30]([C:31]([CH2:40][CH3:41])=[N:32][N:33]3[CH:36]3[CH2:37][CH2:38][CH2:39]3)=[CH:29][CH:28]=2)[CH2:24][CH2:25][N:26]1[C:10](=[O:12])[CH2:9][C:6]1[NH:5][C:4]([CH:1]([CH3:2])[CH3:3])=[N:8][N:7]=1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 58189077HCID 58189077, compoundHCID 178499649HCID 178499649, compound

Product 1

HCID 178437914HCID 178437914, compound

Procedure

Prepared by the method outlined for Example 275 using methyl (5-isopropyl-1H-1,2,4-triazol-3-yl)acetate and 6-((S)-3-benzyl-piperazin-1-yl)-1-cyclobutyl-3-ethyl-1H-indazole as starting materials. Product as a light brown solid (35%). LC/MS (Method B) 3.72 min, [M+1]+ 526.

Workup

  1. customPrepared by the method
  2. customLC/MS (Method B) 3.72 min, [M+1]+ 526

Sources & evidence

ORD record
ord-cab98c53a635411eb2f3753e454af04f
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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