(S)-3-Benzyl-1-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazine → HCID 178491990, compound

HRID 1423209Notes

Reaction equation

HRID 1423209 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:30][C:31](=O)[CH2:32][C:33]1[NH:37][CH:36]=[N:35][N:34]=1)C>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:31](=[O:30])[CH2:32][C:33]1[NH:37][CH:36]=[N:35][N:34]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 16725642(S)-3-Benzyl-1-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazineHCID 178470790HCID 178470790, compound

Product 1

HCID 178491990HCID 178491990, compoundYield 20%

Procedure

Prepared using the same procedure described in Example 275 with (S)-3-benzyl-1-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazine and (4H-[1,2,4]triazol-3-yl)-acetic acid ethyl ester as starting material. The product was obtained as an off-white solid (105 mg, 20%). LC/MS (Method B) 3.39 min, [M+1]+ 476.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-83afca5dcdcb4e42914f7b5ae17aabc7
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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