HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-3-Benzyl-1-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazine → (S)-1-(2-benzyl-4-(3-(cyclopentyloxy)-4-methoxyphenyl)piperazin-1-yl)-2-(1H-pyrazol-4-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-3-Benzyl-1-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazine | HCID 16725642 | — |
| Reactant | methyl 2-(1H-pyrazol-4-yl)acetate | HCID 58189211 | — |
| Product | (S)-1-(2-benzyl-4-(3-(cyclopentyloxy)-4-methoxyphenyl)piperazin-1-yl)-2-(1H-pyrazol-4-yl)ethanone | HCID 58189241 | 7% |
Reaction Steps
Prepared using the same procedure described in Example 275 from (S)-3-benzyl-1-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazine and (1H-pyrazol-4-yl)-acetic acid methyl ester with heating for 15 days to afford the title compound as an off-white solid (12 mg, 7%). LC/MS (Method B) 3.60 min, [M+1]+ 475.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927546B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f4439842bce94487a2d931b56acc24f0 |
| Source note | uspto-grants-2015_01 |