(S)-3-benzyl-1-(3-cyclopropoxy-4-methoxy-phenyl)-piperazine → HCID 178491988, compound

HRID 1423213Notes

Reaction equation

HRID 1423213 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:25][CH2:24]3)[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:28][C:29](=O)[CH2:30][C:31]1[NH:35][CH:34]=[N:33][N:32]=1)C>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:25][CH2:24]3)[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:29](=[O:28])[CH2:30][C:31]1[NH:35][CH:34]=[N:33][N:32]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58189089(S)-3-benzyl-1-(3-cyclopropoxy-4-methoxy-phenyl)-piperazineHCID 178470790HCID 178470790, compound

Product 1

HCID 178491988HCID 178491988, compoundYield 15%

Procedure

Prepared using the same procedure described in Example 275 from (S)-3-benzyl-1-(3-cyclopropyloxy-4-methoxy-phenyl)-piperazine and (4H-[1,2,4]triazol-3-yl)-acetic acid ethyl ester with heating for 7 days to afford the title compound as a yellow solid (20 mg, 15%). LC/MS (Method B) 3.12 min, [M+1]+ 448.

Workup

  1. customPrepared
  2. temperaturewith heating for 7 days

Sources & evidence

ORD record
ord-d379a147df3e414eab18a69ed7b25cf3
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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