HCID 58188985, compound → HCID 66828651, compound

HRID 1423216Notes

Reaction equation

HRID 1423216 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:28][C:29](=O)[CH2:30][C:31]1[NH:32][N:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[N:35]=1>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:29](=[O:28])[CH2:30][C:31]1[NH:32][N:33]=[C:34]([C:36]([F:38])([F:39])[F:37])[N:35]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58188985HCID 58188985, compoundHCID 58189158HCID 58189158, compound

Product 1

HCID 66828651HCID 66828651, compoundYield 15%

Procedure

Prepared using the same procedure described in Example 275 from (S)-3-benzyl-1-(3-cyclobutyloxy-4-methoxy-phenyl)-piperazine and (5-trifluoromethyl-2H-[1,2,4]triazol-3-yl)-acetic acid methyl ester with heating for 5 days to afford the title compound as tan solid (24 mg, 15%). LC/MS (Method B) 3.94 min, [M+1]+ 530.

Workup

  1. customPrepared
  2. temperaturewith heating for 5 days

Sources & evidence

ORD record
ord-2e51fea54d7648d8a7785fcd084d09bb
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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