HCID 58188985, compound → HCID 58189193, compound

HRID 1423218Notes

Reaction equation

HRID 1423218 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:28][C:29](=O)[CH2:30][C:31]1[O:35][C:34]([CH3:36])=[N:33][CH:32]=1>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:29](=[O:28])[CH2:30][C:31]1[O:35][C:34]([CH3:36])=[N:33][CH:32]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58188985HCID 58188985, compoundHCID 66824784HCID 66824784, compound

Product 1

HCID 58189193HCID 58189193, compoundYield 54%

Procedure

Prepared using the same procedure described in Example 275 from (S)-3-benzyl-1-(3-cyclobutyloxy-4-methoxy-phenyl)-piperazine and (2-methyl-oxazol-5-yl)-acetic acid methyl ester with heating for 12 h to afford the title compound as tan solid (110 mg, 54%). LC/MS (Method B) 3.62 min, [M+1]+ 476.

Workup

  1. customPrepared
  2. temperaturewith heating for 12 h

Sources & evidence

ORD record
ord-40410b31add54368b7fff7fab24cf973
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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