HCID 18802133, compound → HCID 66828619, compound

HRID 1423219Notes

Reaction equation

HRID 1423219 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:29][C:30](=O)[CH2:31][C:32]1[NH:33][N:34]=[C:35]([CH:37]([CH3:39])[CH3:38])[N:36]=1)C>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:30](=[O:29])[CH2:31][C:32]1[NH:33][N:34]=[C:35]([CH:37]([CH3:38])[CH3:39])[N:36]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 18802133HCID 18802133, compoundHCID 58188985HCID 58188985, compound

Product 1

HCID 66828619HCID 66828619, compoundYield 25%

Procedure

Prepared using the same procedure described in Example 275 from (S)-3-benzyl-1-(3-cyclobutyloxy-4-methoxy-phenyl)-piperazine and (5-isopropyl-2H-[1,2,4]triazol-3-yl)-acetic acid ethyl ester with heating for 10 h to afford the title compound as tan solid (96 mg, 25%). LC/MS (Method B) 3.39 min, [M+1]+ 504.

Workup

  1. customPrepared
  2. temperaturewith heating for 10 h

Sources & evidence

ORD record
ord-b7cd336e4acc4c0fa168c5b5456f0cdb
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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