6-(3-benzyl-piperazin-1-yl)-1-cyclobutyl-3-ethyl-1H-indazole → HCID 178437915, compound

HRID 1423222Notes

Reaction equation

HRID 1423222 reaction equation
[CH2:1]([CH:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:22]=[C:21]3[C:17]([C:18]([CH2:27][CH3:28])=[N:19][N:20]3[CH:23]3[CH2:26][CH2:25][CH2:24]3)=[CH:16][CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:31][C:32](=O)[CH2:33][C:34]1[NH:38][CH:37]=[N:36][N:35]=1)C>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:22]=[C:21]3[C:17]([C:18]([CH2:27][CH3:28])=[N:19][N:20]3[CH:23]3[CH2:24][CH2:25][CH2:26]3)=[CH:16][CH:15]=2)[CH2:11][CH2:12][N:13]1[C:32](=[O:31])[CH2:33][C:34]1[NH:38][CH:37]=[N:36][N:35]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 668258696-(3-benzyl-piperazin-1-yl)-1-cyclobutyl-3-ethyl-1H-indazoleHCID 178470790HCID 178470790, compound

Product 1

HCID 178437915HCID 178437915, compoundYield 27%

Procedure

Prepared using the same procedure described in Example 275 from 6-(3-benzyl-piperazin-1-yl)-1-cyclobutyl-3-ethyl-1H-indazole and (4H-[1,2,4]triazol-3-yl)-acetic acid ethyl ester with heating for 5 days to afford the title compound as a colorless solid (72 mg, 27%). LC/MS (Method B) 3.52 min, [M+1]+ 484.

Workup

  1. customPrepared
  2. temperaturewith heating for 5 days

Sources & evidence

ORD record
ord-8caf4ff30410419fa5542dd4aec6bee2
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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