HCID 58189227, compound → HCID 178520394, compound

HRID 1423227Notes

Reaction equation

HRID 1423227 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[C:16]([O:24][CH:25]3[CH2:28][CH2:27][CH2:26]3)[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:31][C:32](=O)[CH2:33][C:34]1[NH:38][CH:37]=[N:36][N:35]=1)C>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:22])[F:23])=[C:16]([O:24][CH:25]3[CH2:28][CH2:27][CH2:26]3)[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:32](=[O:31])[CH2:33][C:34]1[NH:38][CH:37]=[N:36][N:35]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58189227HCID 58189227, compoundHCID 178470790HCID 178470790, compound

Product 1

HCID 178520394HCID 178520394, compoundYield 32%

Procedure

Prepared using the same procedure described in Example 275 from (S)-3-benzyl-1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-piperazine and (4H-[1,2,4]triazol-3-yl)-acetic acid ethyl ester with heating for 15 days to afford the title compound as a yellow solid (87 mg, 32%). LC/MS (Method B) 3.64 min, [M+1]+ 498.

Workup

  1. customPrepared
  2. temperaturewith heating for 15 days

Sources & evidence

ORD record
ord-b078be5354a24f93bb7f4063d91e0b2d
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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