Imidazole-4-acetic acid → HCID 178520352, compound

HRID 1423228Notes

Reaction equation

HRID 1423228 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[C:16]([O:24][CH:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:30]1[CH:34]=[C:33]([CH2:35][C:36](O)=[O:37])[N:32]=[CH:31]1>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:22])[F:23])=[C:16]([O:24][CH:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:36](=[O:37])[CH2:35][C:33]1[N:32]=[CH:31][NH:30][CH:34]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 96215Imidazole-4-acetic acidHCID 58189090HCID 58189090, compound

Product 1

HCID 178520352HCID 178520352, compoundYield 26%

Procedure

Prepared using the same procedure described in Example 189 from (S)-3-benzyl-1-(3-cyclopentyloxy-4-difluoromethoxy-phenyl)-piperazine and (1H-imidazol-4-yl)-acetic acid to afford the title compound as colorless solid (46 mg, 26%). LC/MS (Method B) 2.77 min, [M+1]+ 511.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0542cea19f6e4f4f802990590feeab18
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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