Imidazole-4-acetic acid → HCID 178437916, compound

HRID 1423229Notes

Reaction equation

HRID 1423229 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:22]=[C:21]3[C:17]([C:18]([CH2:28][CH3:29])=[N:19][N:20]3[CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)=[CH:16][CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:30]1[CH:34]=[C:33]([CH2:35][C:36](O)=[O:37])[N:32]=[CH:31]1>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:22]=[C:21]3[C:17]([C:18]([CH2:28][CH3:29])=[N:19][N:20]3[CH:23]3[CH2:24][CH2:25][CH2:26][CH2:27]3)=[CH:16][CH:15]=2)[CH2:11][CH2:12][N:13]1[C:36](=[O:37])[CH2:35][C:33]1[N:32]=[CH:31][NH:30][CH:34]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 96215Imidazole-4-acetic acidHCID 23627567HCID 23627567, compound

Product 1

HCID 178437916HCID 178437916, compoundYield 50%

Procedure

Prepared using the same procedure described in Example 189 from (S)-6-(3-Benzyl-piperazin-1-yl)-1-cyclopentyl-3-ethyl-1H-indazole and (1H-imidazol-4-yl)-acetic acid to afford the title compound as colorless solid (66 mg, 50%). LC/MS (Method B) 2.68 min, [M+1]+ 497.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e4148e57448542b69e7d18a7a304cd38
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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