Imidazole-4-acetic acid → HCID 66828518, compound

HRID 1423230Notes

Reaction equation

HRID 1423230 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[C:16]([O:24][CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:29]1[CH:33]=[C:32]([CH2:34][C:35](O)=[O:36])[N:31]=[CH:30]1>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[C:16]([O:24][CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:35](=[O:36])[CH2:34][C:32]1[NH:31][CH:30]=[N:29][CH:33]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 96215Imidazole-4-acetic acidHCID 58189147HCID 58189147, compound

Product 1

HCID 66828518HCID 66828518, compoundYield 35%

Procedure

Prepared using the same procedure described in Example 189 from (S)-3-benzyl-1-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-piperazine and (1H-imidazol-4-yl)-acetic acid to afford the title compound as colorless solid (62 mg, 35%). LC/MS (Method B) 2.80 min, [M+1]+ 497.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-93f7fbf62bf54e908feb40f4b70a4a5f
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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