Imidazole-4-acetic acid → HCID 66828622, compound

HRID 1423231Notes

Reaction equation

HRID 1423231 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[C:16]([O:24][CH:25]([F:27])[F:26])[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:28]1[CH:32]=[C:31]([CH2:33][C:34](O)=[O:35])[N:30]=[CH:29]1>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:22])[F:23])=[C:16]([O:24][CH:25]([F:27])[F:26])[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:34](=[O:35])[CH2:33][C:31]1[NH:30][CH:29]=[N:28][CH:32]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 96215Imidazole-4-acetic acidHCID 52920248HCID 52920248, compound

Product 1

HCID 66828622HCID 66828622, compoundYield 45%

Procedure

Prepared using the same procedure described in Example 189 from (S)-3-benzyl-1-(3,4-bis-difluoromethoxy-phenyl)-piperazine and (1H-imidazol-4-yl)-acetic acid to afford the title compound as colorless solid (55 mg, 45%). LC/MS (Method B) 2.72 min, [M+1]+ 493.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6bb8e81b94904065a31e5aa258576508
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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