2-(3-methyl-1H-1,2,4-triazol-5-yl)acetic acid → HCID 178491986, compound

HRID 1423234Notes

Reaction equation

HRID 1423234 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:25][CH2:24]3)[CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:26][C:27]1[NH:31][N:30]=[C:29]([CH2:32][C:33](O)=[O:34])[N:28]=1>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:25][CH2:24]3)[CH:15]=2)[CH2:11][CH2:12][N:13]1[C:33](=[O:34])[CH2:32][C:29]1[NH:30][N:31]=[C:27]([CH3:26])[N:28]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 70194772-(3-methyl-1H-1,2,4-triazol-5-yl)acetic acidHCID 58189089(S)-3-benzyl-1-(3-cyclopropoxy-4-methoxy-phenyl)-piperazine

Product 1

HCID 178491986HCID 178491986, compoundYield 40%

Procedure

Prepared using the same procedure described in Example 189 from (S)-3-benzyl-1-(3-cyclopropoxy-4-methoxy-phenyl)-piperazine and (5-methyl-1H-[1,2,4]triazol-3-yl)-acetic acid to afford the title compound as colorless solid (53 mg, 40%). LC/MS (Method B) 3.02 min, [M+1]+ 462.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-66eccf09d5b1478a8bbd6eb3e162261b
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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