Chloropyrazine → HCID 52919897, compound

HRID 1423244Notes

Reaction equation

[CH2:1]([CH:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:22]=[C:21]3[C:17]([C:18]([CH2:26][CH3:27])=[N:19][N:20]3[CH:23]([CH3:25])[CH3:24])=[CH:16][CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:29]1[CH:34]=[N:33][CH:32]=[CH:31][N:30]=1>>[CH2:1]([C@@H:8]1[N:13]([C:29]2[CH:34]=[N:33][CH:32]=[CH:31][N:30]=2)[CH2:12][CH2:11][N:10]([C:14]2[CH:22]=[C:21]3[C:17]([C:18]([CH2:26][CH3:27])=[N:19][N:20]3[CH:23]([CH3:24])[CH3:25])=[CH:16][CH:15]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 73277Chloropyrazine

HCID 66825875HCID 66825875, compound

Product 1

HCID 52919897HCID 52919897, compoundYield 12%

Procedure

Prepared using the same procedure described in Example 410 from 6-(3-benzyl-piperazin-1-yl)-3-ethyl-1-isopropyl-1H-indazole and chloropyrazine to afford the title compound as a yellow solid (7 mg, 12%). LC/MS (Method B) 4.47 min, [M+1]+ 441.

Workup

customPrepared

Sources & evidence

ORD record: ord-fa8451b6bc3d419fb78961017c2f492a
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927546B2

Reaction notes

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