2-Chlorothiazole → HCID 58188956, compound

HRID 1423248Notes

Reaction equation

HRID 1423248 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:22]=[C:21]3[C:17]([C:18]([CH2:27][CH3:28])=[N:19][N:20]3[CH:23]3[CH2:26][CH2:25][CH2:24]3)=[CH:16][CH:15]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:30]1[S:31][CH:32]=[CH:33][N:34]=1>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:22]=[C:21]3[C:17]([C:18]([CH2:27][CH3:28])=[N:19][N:20]3[CH:23]3[CH2:24][CH2:25][CH2:26]3)=[CH:16][CH:15]=2)[CH2:11][CH2:12][N:13]1[C:30]1[S:31][CH:32]=[CH:33][N:34]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 764292-ChlorothiazoleHCID 58189077HCID 58189077, compound

Product 1

HCID 58188956HCID 58188956, compoundYield 64%

Procedure

Prepared using the same procedure described in Example 413 from 6-((S)-3-benzyl-piperazin-1-yl)-1-cyclobutyl-3-ethyl-1H-indazole and 2-chlorothiazole to afford the title compound as a colorless solid (152 mg, 64%). LC/MS (Method B) 4.60 min, [M+1]+ 458.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2c12c5262de347ae8a3cbf38ec82cfe5
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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