HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-imidazole-2-carbaldehyde → (S)-5-(4-((1H-imidazol-2-yl)methyl)-3-benzylpiperazin-1-yl)-8-methoxy-2-(trifluoromethyl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-imidazole-2-carbaldehyde | HCID 24955 | — |
| Reactant | (S)-5-(3-benzylpiperazin-1-yl)-8-methoxy-2-(trifluoromethyl)quinoline | HCID 58188941 | — |
| Product | (S)-5-(4-((1H-imidazol-2-yl)methyl)-3-benzylpiperazin-1-yl)-8-methoxy-2-(trifluoromethyl)quinoline | HCID 52920014 | 27% |
Reaction Steps
Prepared using the same procedure described in Example 75 from 5-((S)-3-benzyl-piperazin-1-yl)-8-methoxy-2-trifluoromethyl-quinoline and 1H-imidazole-2-carbaldehyde to afford the title compound as a yellow solid (39 mg, 27%). LC/MS (Method B) 2.85 min, [M+1]+ 482.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927546B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-adf7721f9537497db66de4170aabd265 |
| Source note | uspto-grants-2015_01 |