Hydroxylamine → HCID 86692012, compound

Participants

Reaction Steps

A solution of tert-butyl-2-(7-cyano-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetate (10A, 0.05 g, 0.12 mmol) in 50% NH2OH aqueous solution (3 mL) and 20 μL acetic acid was microwaved under high absorption in N2 atmosphere 105° C. for 40 minutes. The reaction was diluted with EtOAc and washed with water. The organic was concentrated to yield tert-butyl 2-(3-(4-fluorophenyl)-7-(N′-hydroxycarbamimidoyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetate (10B), MS (M+H)=445.

Provenance & Evidence