Trifluoroacetic acid → HCID 68278540, compound

Participants

Reaction Steps

A solution of tert-butyl 2-(3-(4-fluorophenyl)-7-(5-methyl-1,2,4-oxadiazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetate (10C, 25 mg, 0.0534 mmol), was treated with 5 mL 20% TFA in DCM for 14 hours. The reaction was concentrated and purified by reverse phase prep LC to yield 2-(3-(4-fluorophenyl)-7-(5-methyl-1,2,4-oxadiazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetic acid (10, 15.6 mg, 64% yield). MS (M+H)=413.

Provenance & Evidence