反应详情

温度

115 °C

A mixture of tert-butyl 3-cyano-4-oxopyrrolidine-1-carboxylate (60.3 mg, 0.28 mmoL) and 4-(6-phenylpyridin-3-yl)-1H-pyrazol-5-amine (67.8 mg, 0.28 mmoL) in toluene (5 mL) was heated at 115° C. overnight. Concentration afforded crude tert-butyl 8-amino-3-(6-phenylpyridin-3-yl)-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate, which was converted to 3-(6-phenylpyridin-3-yl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidin-8-amine by the treatment of 20% TFA/CH2Cl2 at room temperature: LCMS tR=0.38 Min (5 min run, UV254nm), Mass calculated for, M+328.1, observed LC/MS m/z 329.2 (M+H).

1. concentrationConcentration