1,2-Dichloroethane → HCID 56960961, compound

Participants

Reaction Steps

A mixture of crude 3-(6-phenylpyridin-3-yl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidin-8-amine (0.28 mmol), D-(−)-lactic acid (33.6 mg, 0.37 mmol), EDC (109.7 mg, 0.57 mmol), HOBt (77.6 mg, 0.57 mmol) and DIEA (299.7 uL, 1.72 mmol) in DMF (4 mL) was stirred at room temperature overnight. Purification with prep-LC provided (R)-1-(8-amino-3-(6-phenylpyridin-3-yl)-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-hydroxypropan-1-one: LCMS tR=2.65 Min (10 min run, UV254nm), Mass calculated for, M+400.1, observed LC/MS m/z 401.1 (M+H).

Provenance & Evidence