HCID 68668058, compound → HCID 178466998, compound

HRID 1423354Notes

Reaction equation

HRID 1423354 reaction equation
BrC1C=CC(C2C(N)=CC(OC)=CC=2)=CC=1OC.[Br:19][C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23](/[N:30]=[C:31](/[O:38][CH2:39][CH3:40])\[CH2:32][C:33]([O:35]CC)=O)=[CH:22][CH:21]=1>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[Br:19][C:20]1[CH:21]=[C:22]2[C:23](=[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:29]=13)[N:30]=[C:31]([O:38][CH2:39][CH3:40])[CH:32]=[C:33]2[OH:35]

Participants

4

Reactant 2

HCID 68668058HCID 68668058, compoundHCID 178471903HCID 178471903, compound

Product 1

HCID 178466998HCID 178466998, compound

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent2×

Procedure

To refluxing DOWTHERM A (50 mL) was added the product from Step 2, ethyl (3E)-3-[(4-bromo-1-naphthyl)imino]-3-ethoxypropanoate (5.61 g, 15.4 mmol) in DOWTHERM A (5 mL). The mixture was then heated at this temperature for 5 min, and then cooled to r.t. The mixture was then diluted with hexanes and the resulting solid was removed by filtration. The solid was washed with additional hexanes to yield the title compound as a brown solid. LRMS (M+H)+=318.1.

Workup

  1. temperatureThe mixture was then heated at this temperature for 5 min
  2. customthe resulting solid was removed by filtration
  3. washThe solid was washed with additional hexanes

Sources & evidence

ORD record
ord-6b2b877a27cf4787aea54391a3fba624
Source dataset
uspto-grants-2015_01
Patent number
US08927569B2

Reaction notes

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