Phosphorus oxychloride → HCID 86643480, compound

Participants

Reaction Conditions

Reaction Steps

To the product from Step 3, 8-bromo-9-methoxy-1,3,4,5-tetrahydrophenanthridin-6(2H)-one (880 mg, 2.86 mmol) was added POCl3 (6 mL, 64.4 mmol) and the mixture was heated to 80° C. for 3 h. The excess POCl3 was then removed in vacuo, the residue was dissolved in DCM and the pH was adjusted to 5 with 1N NaOH. The organic layer was then dried over Na2SO4 and the solvent was removed in vacuo. The resulting solid was tritrated with ether to yield the title compound as a light yellow solid. LRMS (M+H)+=325.8.

Provenance & Evidence