反应详情

A reaction flask equipped with a mechanical stirrer, a reflux condenser and a nitrogen bubbler is charged with EtOH (5000 mL), 3-amino-5-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester from example A2 (565.57 g; 2.50 mol) and formamidine acetate (1041.10 g; 10.00 mol). The well-stirred reaction mixture is heated to gentle reflux for five days under an atmosphere of nitrogen.

1. customA reaction flask equipped with a mechanical stirrer, a reflux condenser
2. customThe well-stirred reaction mixture
3. temperatureis heated
4. temperatureto gentle reflux for five days under an atmosphere of nitrogen