HRID1423443

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2724271

2-Chloromethyl 2-(trimethylsilyl)ethyl ether

C6H15ClOSi

反应SMILES：CCOC(=O)c1c(C)[nH]c2c(-c3cc(C(F)(F)F)ccc3OCC3CC3)ncnc12

HCID67955636

未命名化合物

PRODUCTS

产物

反应SMILES：CCOC(=O)c1c(C)n(COCC[Si](C)(C)C)c2c(-c3cc(C(F)(F)F)ccc3OCC3CC3)ncnc12

HCID67033638

未命名化合物

PROCEDURE

实验过程

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate (example D.a8) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title compound is obtained as yellow viscous oil.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-9c87f0694a504a0f9d5f0d58518a0d5e
来源数据集: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08927557B2
来源说明: uspto-grants-2015_01

反应SMILES

[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:7]=2[C:16]2[C:17]3[NH:24][C:23]([CH3:25])=[C:22]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:3][CH2:2]1.Cl[CH2:32][O:33][CH2:34][CH2:35][Si:36]([CH3:39])([CH3:38])[CH3:37]>>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]([F:14])([F:13])[F:15])=[CH:8][C:7]=2[C:16]2[C:17]3[N:24]([CH2:32][O:33][CH2:34][CH2:35][Si:36]([CH3:39])([CH3:38])[CH3:37])[C:23]([CH3:25])=[C:22]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:3][CH2:2]1