2-Chloromethyl 2-(trimethylsilyl)ethyl ether → Ethyl 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-Chloromethyl 2-(trimethylsilyl)ethyl ether	HCID 2724271	—
Reactant	Ethyl 4-(2-cyclopropylmethoxy-4-fluoro-5-methoxy-phenyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate	HCID 67956798	—
Product	Ethyl 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate	HCID 67955139	—

Reaction Steps

Starting from 4-(2-cyclopropylmethoxy-4-fluoro-5-methoxy-phenyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester (example D.a10) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title compound is obtained as yellow viscous oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08927557B2
Source dataset	uspto-grants-2015_01
ORD ID	ord-3a0987a491144bc8afc9b4365804ca4a
Source note	uspto-grants-2015_01