2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 67956967, compound

HRID 1423448Notes

Reaction equation

HRID 1423448 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3([CH3:17])[O:16][CH2:15][CH2:14][O:13]3)=[CH:8][C:7]=2[C:18]2[C:19]3[NH:26][C:25]([CH3:27])=[C:24]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[C:20]=3[N:21]=[CH:22][N:23]=2)[CH2:3][CH2:2]1.Cl[CH2:34][O:35][CH2:36][CH2:37][Si:38]([CH3:41])([CH3:40])[CH3:39]>>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3([CH3:17])[O:13][CH2:14][CH2:15][O:16]3)=[CH:8][C:7]=2[C:18]2[C:19]3[N:26]([CH2:34][O:35][CH2:36][CH2:37][Si:38]([CH3:41])([CH3:40])[CH3:39])[C:25]([CH3:27])=[C:24]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[C:20]=3[N:21]=[CH:22][N:23]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 67956976HCID 67956976, compound

Product 1

HCID 67956967HCID 67956967, compound

Procedure

Starting from ethyl 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1,3-dioxolan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate (example D.a13) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title compound is obtained as yellow viscous oil.

Sources & evidence

ORD record
ord-3c972ae432694c2db5158dd7de479758
Source dataset
uspto-grants-2015_01
Patent number
US08927557B2

Reaction notes

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