(3R,4R)-3-Amino-1-Boc-4-hydroxypyrrolidine → tert-Butyl(3r,4r)-3-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin-7-yl)carbonyl]amino}-4-hydroxypyrrolidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	(3R,4R)-3-Amino-1-Boc-4-hydroxypyrrolidine	HCID 11275699	—
Reactant	4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid	HCID 67956161	—
Product	tert-Butyl(3r,4r)-3-{[(4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidin-7-yl)carbonyl]amino}-4-hydroxypyrrolidine-1-carboxylate	HCID 67956608	—

Reaction Steps

Starting from 4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example D.c2) and commercially available tert-butyl(3R*,4R*)-3-amino-4-hydroxy-pyrrolidine-1-carboxylate the title compound is obtained as pale yellow viscous oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08927557B2
Source dataset	uspto-grants-2015_01
ORD ID	ord-840570918f784f61949e865466b50ca1
Source note	uspto-grants-2015_01