4-Amino-1-Boc-piperidine → HCID 67956123, compound

HRID 1423463Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[C:12]2[N:19]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[C:18]([CH3:28])=[C:17]([C:29]([OH:31])=O)[C:13]=2[N:14]=[CH:15][N:16]=1)[CH3:2].[NH2:32][CH:33]1[CH2:38][CH2:37][N:36]([C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[CH2:35][CH2:34]1>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[C:12]2[N:19]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:26])([CH3:25])[CH3:27])[C:18]([CH3:28])=[C:17]([C:29]([NH:32][CH:33]3[CH2:34][CH2:35][N:36]([C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[CH2:37][CH2:38]3)=[O:31])[C:13]=2[N:14]=[CH:15][N:16]=1)[CH3:2]

Participants

Reactant 2

HCID 12682914-Amino-1-Boc-piperidine

HCID 67033207HCID 67033207, compound

Product 1

HCID 67956123HCID 67956123, compound

Procedure

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example D.c4) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as pale yellow foam.

Sources & evidence

ORD record: ord-c1d8c14fb5b64096b07589bb03823556
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927557B2

Reaction notes

Loading…