HCID 67033074, compound → HCID 178429357, compound

HRID 1423501Notes

Reaction equation

HRID 1423501 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3([CH3:17])[O:16][CH2:15][CH2:14][O:13]3)=[CH:8][C:7]=2[C:18]2[C:19]3[N:26]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[C:25]([CH3:35])=[C:24]([C:36]([OH:38])=O)[C:20]=3[N:21]=[CH:22][N:23]=2)[CH2:3][CH2:2]1.[NH2:39][C@H:40]1[CH2:45][CH2:44][C@H:43]([NH:46][C:47](=[O:53])[O:48][C:49]([CH3:52])([CH3:51])[CH3:50])[CH2:42][CH2:41]1>>[C:49]([O:48][C:47](=[O:53])[NH:46][C@H:43]1[CH2:42][CH2:41][C@H:40]([NH:39][C:36]([C:24]2[C:20]3[N:21]=[CH:22][N:23]=[C:18]([C:7]4[CH:8]=[C:9]([C:12]5([CH3:17])[O:13][CH2:14][CH2:15][O:16]5)[CH:10]=[CH:11][C:6]=4[O:5][CH2:4][CH:1]4[CH2:3][CH2:2]4)[C:19]=3[N:26]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:33])([CH3:32])[CH3:34])[C:25]=2[CH3:35])=[O:38])[CH2:45][CH2:44]1)([CH3:52])([CH3:50])[CH3:51]

Participants

3

Reactant 2

HCID 67033074HCID 67033074, compoundHCID 178419079HCID 178419079, compound

Product 1

HCID 178429357HCID 178429357, compound

Procedure

Starting from 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1,3-dioxolan-2-yl)phenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example D.c13) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil.

Sources & evidence

ORD record
ord-d4cc5c74affa4c60a39efb8b0a69812e
Source dataset
uspto-grants-2015_01
Patent number
US08927557B2

Reaction notes

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