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HRID 1423509作成日：2026年10月25日

4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid → tert-Butyl {(1S*,3S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]-3-methylcyclohexyl}carbamate

https://huagongshe.com/reaction/1423509

反応式

関与物質

役割名称HCID仕込み量
反応物4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acidHCID 67956012—
反応物tert-butyl[(1R*,3R*,4R*)-4-amino-3-methylcyclohexyl]carbamateHCID 131116877—
生成物tert-Butyl {(1S*,3S*,4S*)-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]-3-methylcyclohexyl}carbamateHCID 86666651—

反応手順

Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example D.g1) and tert-butyl [(1R*,3R*,4R*)-4-amino-3-methylcyclohexyl]carbamate (example C11) the title compound is obtained as pale yellow foam.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08927557B2
出典データセットuspto-grants-2015_01
ORD IDord-1cf15830053540b6a106763ddec2b19a
出典メモuspto-grants-2015_01